James J. Bull

Bull, James J.
Johann Friedrich Miescher Regents Professor in Molecular Biology

E-mail: bull@mail.utexas.edu

Website: http://www.zo.utexas.edu/faculty/antisense/

Main Office: PAT 131
Phone: 471-8266

Alternate Office: PAT 128-138
Phone: (512) 471-5661

Mailing Address:
The University of Texas at Austin - ICMB
1 University Station C0930
2415 Speedway
Austin, TX 78712-1095

Graduate Students:

  • Harcombe, William
  • Heineman, Richard

    • Post Doc Students:

  • Brown, Sam

    • Research Summary:
       see section bio for more info
    Evolutionary genetics from the molecular to the phenotypic levels comprises the bulk of my research. Specific topics include the evolution of virulence, evolutionary robustness and redundancy, the genetic basis of adaptation, and phylogeny reconstruction. Experimental systems are developed in which evolution occurs over short time periods in the laboratory; the evolved lines are then analyzed at the molecular genetic level, so that the course of evolution is known with certainty. Research organisms are chiefly bacteriophage, enabling complete genome sequencing. Students are encouraged to initiate their research on a well-defined model system to gain experience and then expand their research to problems of their own design.
     
    Publications:
    Sex determination: some like it hot (and some don't) (2008) Nature 451, 527-528.
    Experimental evolution of gene duplicates in a bacterial plasmid model (2007) J Mol Evol 64, 15-22.
    Testing optimality with experimental evolution: lysis time in a bacteriophage (2007) Evolution Int J Org Evolution 61, 1695-1709.
    Pharmacodynamics of non-replicating viruses, bacteriocins and lysins (2006) Proc Biol Sci 273, 2703-2712.

     
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