James J. Bull

Bull, James J.
Johann Friedrich Miescher Regents Professor in Molecular Biology

E-mail: bull@mail.utexas.edu

Website: http://www.zo.utexas.edu/faculty/antisense/

Main Office: PAT 131
Phone: 471-8266

Alternate Office: PAT 128-138
Phone: (512) 471-5661

Mailing Address:
The University of Texas at Austin - ICMB
1 University Station C0930
2415 Speedway
Austin, TX 78712-1095

Research Summary:
   Evolutionary genetics from the molecular to the phenotypic levels comprises the bulk of my research. Specific topics include the evolution of engineered genomes, microbial drug resistance, and adaptation addressed empirically and theoretically. Experimental systems are developed in which evolution occurs over short time periods in the laboratory; the evolved lines are then analyzed at the molecular genetic level, so that the course of evolution is known with certainty. Research organisms are chiefly bacteriophage, enabling complete genome sequencing. Students are encouraged to initiate their research on a well-defined model system to gain experience and then expand their research to problems of their own design.
Evolution at a high imposed mutation rate: adaptation obscures the load in phage T7 (2010) Genetics 184(1), 221-32.
A tale of tails: Sialidase is key to success in a model of phage therapy against K1-capsulated Escherichia coli. (2010) Virology 398(1), 79-86.
Viral resistance evolution fully escapes a rationally designed lethal inhibitor (2009) Molecular Biology and Evolution 26(9), 2041-6.
Predicting evolution from genomics: experimental evolution of bacteriophage T7 (2008) Heredity 100(5), 453-63.
Lethal mutagenesis of bacteria (2008) Genetics 180(2), 1061-70.

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