Robin Gutell

Gutell, Robin
Professor in Integrative Biology

E-mail: robin.gutell@mail.utexas.edu

Website: http://www.biosci.utexas.edu/IB/faculty/GUTELL.HTM

Main Office: PAT 141MB
Phone: (512) 232-4814

Alternate Office: PAT 141
Phone: (512) 232-4815

Mailing Address:
The University of Texas at Austin
Integrative Biology, 1 University Station - C0930
PAT 141, 2401 Speedway
Austin, TX 78712

Graduate Students:

  • Gardner, David
  • Jiang, Yanan
  • Shang, Lei

    • Post Doc Students:

    Research Summary:
       see section bio for more info

    The remarkable advances in Nucleic Acid sequencing and Computer technology is transforming Biology to a new level of understanding. We are now attempting to understand many biological and biochemical processes, and complex structures from a molecular sequence and molecular evolution perspective, utilizing computational biology and bioinformatics. Within this new frontier my lab is primarily interested in RNA structure and the evolution of these RNAs.

    Currently we are addressing the following topics -

    (1) STRUCTURE PREDICTION: RNA secondary and tertiary structure prediction with comparative sequence analysis.
    (2) PRINCIPLES OF RNA STRUCTURE: Relationships between RNA sequence and RNA higher order structure.
    (3) RNA FOLDING: transforming a single RNA sequence into its biologically correct higher order structure.
    (4) PHYLOGENETIC ANALYSIS: Inferring phylogenetic and evolutionary relationships from RNA structures.
    (5) WWW DATABASES: RNA sequence/structure web knowledgebase.

    The lab seeks an interdisciplinary group of people, with interests in RNA structure, Molecular Biology, Molecular Evolution, Computer Science, and Applied Mathematics.


     
    Publications:
    Correlation of Comparative Sequence Frequency and Thermodynamic Stability of RNA Secondary Structures (2009) Journal of Molecular Biology. 391, 769-783.
    The UAA/GAN Internal Loop Motif: A New RNA Structural Element That Forms a Cross-strand AAA stack and Long-range Tertiary Interactions. (2006) Journal of Molecular Biology 360, 978-988.
    Diversity of Base-pair Conformations and their Occurrence in rRNA Structure and RNA Structural Motifs (2004) Journal of Molecular Biology 344, 1225-1249.
    Evaluation of the suitability of free-energy minimization using nearest-neighbor energy parameters for RNA secondary structure prediction (2004) BioMed Central Bioinformatics 5, 105.
    The Lonepair Triloop: A New Motif in RNA Structure (2003) Journal of Molecular Biology 325, 65-83.
    The Accuracy of Ribosomal RNA Comparative Structure Models (2002) Current Opinion in Structural Biology 12, 301-310.
    The Comparative RNA Web (CRW) Site: An Online Database of Comparative Sequence and Structure Information for Ribosomal, Intron, and Other RNAs (2002) BioMed Central Bioinformatics 3, 2 (and 15).

     
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