Faculty

Nigel Atkinson

Atkinson, Nigel
Professor in Neurobiology

E-mail

Website

Main Office: PAT 228
Phone: 232-3404

Alternate Office: PAT 230
Phone: (512) 471-1629

Mailing Address:
The University of Texas at Austin
Neurobiology, Section of
1 University Station C0920
Austin, TX 78712-0248
Research Lab Students:
  • AlHazan, Yazan
  • Krishnan, Harish
  • Li, Xiaolei
  • Pohl, Jascha
  • Ramazani, Rosie
  • Wang, Yan (Diane)

    • Research Summary:

    The fundamental question that drives us is: How are ion channel genes regulated and what are the consequences of this regulation? To address this question we have been using the slowpoke gene of Drosophila as a model. The slowpoke gene encodes the BK-type Ca2+-activated K+ channel. In insects and mammals these channels are used in both nervous tissue and muscle. In humans this channel plays a central role in controlling blood pressure. Our work shows that slowpoke is homeostatically regulated. Treatments that reduce neural excitability enhance slowpoke expression while treatments that increase activity reduce slowpoke expression. Both of these changes are postulated to shift the nervous system back towards a more normal level of excitability. In this vein, we have developed a Drosophila model of tolerance to drugs of abuse. In this model, flies sedated one time with either ethanol or an organic solvent acquire tolerance to solvent sedation. Tolerance is reduced drug response responsiveness caused by prior drug exposure and is a factor that leads one to addiction. We have shown that sedation also induces slowpoke expression and that slowpoke is absolutely required for the production of behavioral tolerance. Electrophysiological assays show that increased slowpoke enhances neural excitability in a manner postulated to resist sedation and to produce tolerance. At this time, we are identifying the transcriptional mechanisms that slowpoke uses to monitor and respond to state of neural activity. We have observed that drug sedation causes changes in chromatin remodeling and how that these changes leads to increased channel expression.
    Research Images:

    Ring of Flies

    One fly

    Still another fly

    Three Ring Flies

    Electrodes and a fly

    me

    portrait

     
    Publications:
    2007Wang, Y, Krishnan, HR, Ghezzi, A, Yin, JCP, Atkinson, NS , Drug-induced epigenetic changes produce drug tolerance, PLoS-Biology 5:e265 view.
    2007Ramazani RB, Krishnan HR, Bergeson SE, Atkinson, NS, Computer automated movement detection for the analysis of behavior, J. Neuroscience Methods 162:171-191.
    2007Fernandez, Mde L, Chu J, Villella A, Atkinson N, Kay SA, Ceriani MF, Impaired clock output by altered connectivity in the circadian network, Proc Natl Acad Sci U S A 104:5650-5655.
    2006Yu JY, Updadyaya A, Atkinson NS , Tissue-specific alternative splicing of BK channel transcripts in Drosophila., Genes, Brain & Behavior 5:329-339.

     
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