Faculty

Janice Fischer

Fischer, Janice
Professor in Molecular Cell & Developmental Biology

E-mail

Website

Main Office: MBB 1.312AA
Phone: 471-5831

Alternate Office: MBB 1.312A & B
Phone: 471-2826

Mailing Address:
The University of Texas at Austin - ICMB
1 University Station A4800
2500 Speedway
Austin, TX 78712-1095
Research Lab Students:
  • Banks, Susie
  • Cho, Bomsoo
  • Lee, Ji-Hoon
  • Van der Ende, Gerrit
  • Xie, Xuanhua

    • Research Summary:

    My laboratory uses Drosophila genetics and molecular biology to study universal mechanisms of development. We do most of our experiments with the Drosophila compound eye. Patterning of the Drosophila compound eye involves nearly every known cell signaling pathway and the eye affords many experimental advantages. We are studying how cell-cell interactions are regulated by membrane trafficking and ubiquitin. Also, are using a Drosophila model to understand Angelman syndrome, a human neurological disease caused by loss of function of a gene called UBE3A. UBE3A encodes a specificity factor for ubiquitination. We are using Drosophila genetics to understand the function of UBE3A and the biochemical effects of its loss relevant to Angelman syndrome.
    Publications:
    2009Lee J-H, Overstreet E, Fitch E, Fleenor, Fischer JA , Drosophila liquid facets-Related encodes Golgi epsin and is an essential gene required for cell proliferation, growth, and patterning. , Developmental Biology in press:.
    2008Wu Y, Bolduc FV, Bell K, Tully T, Fang Y, Sehgal A, Fischer JA, A Drosophila model for Angelman syndrome, Proceedings of the National Academy of Sciences, USA 105:12399-12404.
    2008Eun SH, Banks S, Fischer JA , Auxilin is essential for Delta signaling, Development 135:1089-1095.
    2007Eun SH, Lea K, Overstreet E, Stevens S, Lee J-H, Fischer JA, Identification of genes that interact with Drosophila liquid facets, Genetics 175:1163-1174.
    2006Fischer JA, Eun SH, Doolan BT, Endocytosis, endosome trafficking and the regulation of Drosophila development, Annual Review of Cell and Developmental Biology 22:181-206.
    2004Overstreet E, Fitch E, Fischer JA , Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells, Development 131:5355-5366.
    2003Overstreet E, Chen X, Wendland B, Fischer JA , Either part of a Drosophila epsin (Liquid facets) protein, divided after the ENTH domain, functions in the internalization of Delta in the developing eye, Current Biology 13:854-860.
    2002Chen X, Zhang B, Fischer, JA , A specific protein substrate for a deubiquitinating enzyme: Liquid facets is the substrate of Faf facets, Genes and Development 16:289-294.

     
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