Faculty
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Bratton, Shawn
Associate Professor in Pharmacology and Toxicology
E-mail Website Main Office: PHR 5.218A
Phone: (512) 471-1735 Alternate Office: PHR 6.210/6.218
Phone: (512) 471-5098 Mailing Address:
The University of Texas at Austin
1 University Station
College of Pharmacy, 2409 University Ave.
Austin, TX 78712-0215
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Research Summary:
My laboratory focuses primarily on basic mechanisms of apoptosis (programmed cell death) and autophagy (self-cannibalism) in the context of cancer.
Publications:| 2009 | Malladi, S., Challa-Malladi, M., Fearnhead, H.O., and Bratton, S.B., The Apaf-1•pro-caspase-9 apoptosome complex functions as a proteolytic-based molecular timer, EMBO J. 28:1916-1925. | | 2009 | Choi, Y. E., Butterworth, M., Malladi, S., Duckett, C. S., Cohen, G. M., and Bratton, S. B., The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspases-3 and -7 via unique mechanisms at distinct steps in their processing, J. Biol. Chem. 284:12772-12782. | | 2007 | Milleron, R.S., and Bratton, S.B., 'Heated' debates in apoptosis, Cell Mol. Life Sci. 64:2329-2333. | | 2007 | Challa, M., Malladi, S., Pellock, B. J., Dresnek, D., Varadarajan, S., Yin, Y. W., White, K., and Bratton, S. B., Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease, EMBO J. 26:3144-3156. | | 2006 | Mufti, A. R., Burstein, E., Csomos, R. A., Graf, P. C., Wilkinson, J. C., Dick, R. D., Challa, M., Son, J. K., Bratton, S. B., Su, G. L., Brewer, G. J., Jakob, U., and Duckett, C. S., XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders, Mol. Cell 21:775-785. | | 2006 | Chandra, D., Bratton, S. B., Person, M. D., Tian, Y., Martin, A. G., Ayres, M., Fearnhead, H. O., Gandhi, V., and Tang, D. G., Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting the apoptosome, Cell 125:1333-1346. | | 2006 | Milleron, R. S., and Bratton, S. B., Heat shock induces apoptosis independently of any known initiator caspase-activating complex, J. Biol. Chem. 281:16991-17000. |
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