Research Summary || Recent References || Positions Available
|| Home Page ||

RECENT Publications (since 1994)

Books

1. Flint, J., Enquist, L. W., Krug, R.M., Racanniello, V. and Skalka, A.M. (1999)
   Animal Virolgy: Principles of Molecular Biology, Pathogenesis and Control.
   ASM Press, Washington.

Journal Articles

1. Lamb, R.A. and Krug, R.M. (2000).
   Orthomyxoviridae: the viruses and their replication.
   In Virology, 4th edition (David M. Knipe and P. W. Howley, eds.) Lippincott-Raven Press, New York, in press.
2. Chen, Z. and Krug, R. M. (2000).
   Selective nuclear export of viral messenger RNAs in influenza virus-infected cells.
   Trends in Microbiology, in press.
3. Chen, Z., Li, Y. and Krug, R. M. (1999).
   Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3' end processing machinery.
   EMBO J., 18: 2273-2283.
4. Wang, W., Riedel, K., Lynch, K., Chien, C., Montelione, G. T. and Krug, R. M. (1999).
   RNA-binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids.
   RNA 5: 195-205.
5. Li, M.-L., Ramirez, C. and Krug, R.M. (1998) .
   RNA-dependent activation of primer RNA production by the influenza virus polymerase: Different regions of the same protein subunit constitute the two required RNA-binding sites.
   EMBO J. 17: 5844-5852.
6. Li, Y., Yamakita, Y. and Krug, R.M. (1998)
   Regulation of a nuclear export signal by an adjacent inhibitory sequence: the effector domain of the influenza virus NS1 protein.
   Proc. Natl. Acad. Sci USA 95: 4864-4869.
7. Nemeroff, M.E., Barabino, S.M.L., Li, Y., Keller, W. and Krug, R.M. (1998)
   Influenza virus NS1 protein interacts with the cellular 30kD subunit of CPSF and inhibits 3' end formation of cellular mRNAs.
   Molecular Cell 1: 991-1000.
8. Krug, R. M. (1998).
   Unique functions of the NS1 protein. In Textbook of Influenza (Nicholson, K. G., Webster, R. G. and Hay, A., eds.).
   Blackwell Science Ltd., London, pp. 82-92.
9. Chen, Z., Li, Y. and Krug, R.M. (1998).
   Chimeras containing influenza NS1 and HIV-1 Rev protein sequences: mechanism of their inhibition of nuclear export of Rev protein-RNA complexes.
   Virology 241: 234-250.
10. Wang, W. and Krug, R. M. (1998).
    U6atac snRNA, the highly divergent counterpart of U6 snRNA, is the specific target that mediates inhibition of AT-AC splicing by the influenza virus NS1 protein.
    RNA 4: 55-64.
11. Liu, J., Lynch, P. A., Chien, C., Montelione, G. T., Krug, R. M. and Berman, H. M. (1997).
    Crystal structure of the unique multifunctional RNA-binding domain of the influenza virus NS1 protein.
    Nature Struct. Biol. 4: 896-899.
12. Chien, C., Tejero, R., Huang, Y., Zimmerman, D.E., Rios, C.B., Krug, R.M. and Montelione, G. T. (1997).
    A novel RNA-binding motif in influenza A virus non-structural protein 1.
    Nature Struct. Biol.4: 891-895.
13. Shih, S.R. and Krug, R.M. (1996).
    Surprising function of the three influenza viral polymerase proteins: selective protection of viral mRNAs against the cap-snatching reaction catalyzed by the same polymerase proteins.
    Virology 226: 430-435.
14. Shih,S.-R. and Krug, R. M. (1996).
    Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential M2 ion channel protein in infected cells.
    EMBO J 15: 5415-5427.
15. Wang, W. and Krug, R.M. (1996).
    The binding and effector domains of the viral NS1 protein are conserved to different extents among influenza A and B viruses.
    Virology 223: 41-50.
16. Qian, X.Y., Zhang, J., Rabson, A.B. and Krug, R.M. (1996).
    New approach for inhibiting rev function and HIV-1 production using the influenza virus NS1 protein.
    Proc. Natl. Acad. Sci. USA 93: 8873-8877.
17. Lamb, R.A. and Krug, R.M. (1996).
    Orthomyxoviridae: the viruses and their replication. In Virology, 3rd edition (R.N. Fields and David M. Knipe, eds.)
    Lippincott-Raven Press, New York, pp. 1353-1395.
18. Qian, X.Y., Chien, C., Montelione, G. and Krug, R.M. (l995).
    An amino terminal polypeptide fragment of the influenza virus NS1 protein possesses specific RNA-binding activity and is largely alpha-helical.
    RNA 1: 948-956.
19. Lu, Y., Wambach, M., Katze, M. G. and Krug, R.M. (1995).
    Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the eIF-2 translation initiation factor.
    Virology 214: 222-228.
20. Nemeroff, M.E., Qian, X.-Y. and Krug, R.M. (1995).
    The influenza virus NS1 protein forms multimers in vitro and in vivo.
    Virology 212: 422-428.
21. Shih, S-R., Nemeroff, M. and Krug, R.M. (1995).
    The choice of alternative 5' splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex.
    Proc. Natl. Acad. Sci. USA 92: 6324-6328.
22. Qiu, Y., Nemeroff, M. and Krug, R.M. (1995).
    The influenza virus NS1 protein binds to a specific sequence in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA.
    RNA 1: 304-316.
23. Lu, Y. Qian, X-Y., and Krug, R.M. (1994).
    The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing.
    Genes Dev. 8: 1817-1828.
24. Qian, X-Y, Alonso-Caplen, F., Qui, Y. and Krug, R.M. (1994).
    Two functional domains of the influenza NS1 protein are required for the regulation of the nuclear export of mRNA.
    J. Virol. 68: 2433-2441.
25. Qiu, Y. and Krug, R.M. (1994).
    The influenza virus NS1 protein is a poly A-binding protein that inhibits the nuclear export of mRNAs containing poly A.
    J. Virol. 68: 425-432.