Richard Aldrich

Aldrich, Richard
Professor and Chair of Neurobiology
Karl Folkers Chair in Interdisciplinary Biomedical Research II
The National Academy of Sciences, member

E-mail: raldrich@mail.utexas.edu

Website: http://clm.utexas.edu/AldrichLab/

Main Office: NMS 5.104
Phone: 512-232-6246

Mailing Address:
Center for Learning and Memory
1 University Station C7000
University of Texas at Austin
Austin, TX 78712-0805

Graduate Students:

  • Litchfield, Justin D

    • Post Doc Students:

  • Chen, Xixi
  • Greeson, Jennifer
  • Halling, D. Brent
  • Liu, He
  • Luik, Riina
  • Scott, Luisa
  • Yan, Jiusheng

    • Research Summary:
       Ion channels are the molecular units of electrical signaling in cells. They are proteins that regulate the movement of ions--such as sodium, calcium, and potassium--into and out of cells. They are responsible for the conversion of external sensory signals to the electrical language of the nervous system and for the integration of these signals to generate appropriate behavior. Ion channels are also important for the generation and regulation of the heartbeat, for contraction of muscles, and for the release of hormones in the bloodstream. The body contains a large variety of ion channel types, specialized to select for certain species of ions and to selectively open and close in response to a number of different stimuli, such as the binding of a neurotransmitter molecule or a change in the voltage that exists across a cell's membrane. Work in the Aldrich laboratory is directed towards understanding the mechanisms of ion channel function and the role of ion channels in electrical signaling and physiology. This research relates to transduction, processing, and transmission of information in the nervous other physiological systems and to basic mechanisms of coupled conformational changes in signaling proteins. We use a combination of molecular biology, electrophysiology, biophysics, cellular and systems physiology, and computational biology.
     
    Research Images:

    Opening and closing of a single potassium channel protein

     
    Publications:
    Activation of the SK potassium channel-calmodulin complex by nanomolar concentrations of terbium. (2009) Proc Natl Acad Sci U S A 106, 1075-80.
    Convergent Evolution of Alternative Splices at Domain Boundaries of the BK Channel. (2009) Annu Rev Physiol. 71, 19-36.
    EF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK-calmodulin interaction. (2009) J Gen Physiol 134, 281-93.
    The molecular mechanism of "ryegrass staggers," a neurological disorder of K+ channels. (2008) J Pharmacol Exp Ther. 327, 657-64.
    Profiling the phospho-status of the BKca channel a subunit in rat brain reveals unexpected patterns and complexity. (2008) Mol Cell Proteomics. 7, 2188-98.
    Local potassium signaling couples neuronal activity to vasodilation in the brain (2006) Nat Neurosci. 9, 1397-1403.
    State-independent block of BK channels by an intracellular quaternary ammonium. (2006) J Gen Physiol. 128, 347-364.
    BK calcium-activated potassium channels regulate circadian behavioral rhythms and pacemaker output (2006) Nat. Neurosci. 9, 1041-1049.
    Relationship between pore occupancy and gating in BK potassium channels (2006) Journal of General Physiology 127, 557-576.
    Statistical limits to the identification of ion channel domains by sequence similarity (2006) Journal of General Physiology 127, 775-766.
    BK channel 4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures (2005) Nature Neuroscience 8, 1752-1759.
    Influence of Conservation on Calculations of Amino Acid Covariance in Multiple sequence Alignments. (2004) Proteins: Structure, Function and Bioinformatics 56, 211-221.
    On evolutionary conservation of thermodynamic coupling in proteins. (2004) Journal of Biological Chemistry 279, 19046-19050.
    A gastropod toxin selectively slows early transitions in the Shaker K channel�s activation pathway. (2004) Journal of General Physiology 123, 685-696.
    Unique inner pore properties of BK channels revealed by quaternary ammonium block. (2004) Journal of General Physiology 124, 43-57.
    Calcium activation of BKCa potassium channels lacking calcium bowl and RCK domains (2002) Nature 420, 499-502.
    Coupling Between voltage-sensor Activation, Ca 2+ binding and Channel Opening in large Conductance (BK) Potassium Channels (2002) Journal of General Physiology 120, 267-305.
    Regulation of arterial tone and blood pressure by the beta1 subunit of the calcium-activated potassium (BK) channel (2000) Nature 407, 870-876.

     
    Search PubMed for more publications by Prof. Name
    (a new browser window will open)
    "Caution, this search may require more information to be accurate or specific. Check authors and institution carefully."

    Max Docs:  Pub. Date limit: