John Wallingford

Wallingford, John
Associate Professor in Molecular Cell & Developmental Biology

E-mail: wallingford@mail.utexas.edu

Website: http://www.bio.utexas.edu/faculty/wallingford/index.html

Main Office: PAT 222
Phone: 232-2784

Mailing Address:
The University of Texas at Austin
1 University Station C0930
Austin, TX 78712-0195
Research Summary:
   The process by which embryos acquire their final shape involves the coordination of cell fate decisions with cell movement. We are taking an integrated approach to understanding this process in vertebrate embryos. We combine molecular manipulations, time-lapse imaging, and old-fashioned cut & paste embryology to investigate molecular signaling, individual cell behavior, and tissue rearrangement. By considering all of these components and how they affect the final body plan, we hope to build a comprehensive picture of early embryonic morphogenesis.
 
Research Images:

Axolotl Neural plate

Xenopus Neural Plate

Xenopus neurula








 
Publications:
Direct activation of Shroom3 transcription by Pitx proteins drives epithelial morphogenesis in the developing gut. (2010) Development 137, 1339-49.
In vivo imaging reveals a role for Cdc42 in spindle positioning and planar orientation of cell divisions during vertebrate neural tube closure. (2009) J Cell Sci 122, 2481-90.
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. (2009) Nat Cell Biol 11, 1225-35.
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. (2008) Nat. Genet. 40, 871-9.
Developmental Regulation of Central Spindle Assembly and Cytokinesis during Vertebrate Embryogenesis (2008) Curr Biol 18, 116-123.
Vertebrate gastrulation: the BMP sticker shock (2007) Curr Biol 17, R206-9.
Identification of novel ciliogenesis factors using a new in vivo model for mucociliary epithelial development (2007) Dev Biol 312, 115-130.
Shroom family proteins govern alpha-tubulin distribution and microtubule architecture during epithelial cell shape change. (2007) Development 134, 1431-1441.
Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium. (2006) Development 133, 4109-4118.
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling (2006) Nature Genetics 38, 303-311.

 
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