John Wallingford

Wallingford, John
Associate Professor in Molecular Cell & Developmental Biology

E-mail: wallingford@austin.utexas.edu

Website: http://www.bio.utexas.edu/faculty/wallingford/index.html

Main Office: PAT 222
Phone: 232-2784

Mailing Address:
The University of Texas at Austin
Patterson Labs
2401 Speedway
Austin, TX 78712-0195


Research Summary:
   The process by which embryos acquire their final shape involves the coordination of cell fate decisions with cell movement. We are taking an integrated approach to understanding this process in vertebrate embryos. We combine molecular manipulations, time-lapse imaging, and old-fashioned cut & paste embryology to investigate molecular signaling, individual cell behavior, and tissue rearrangement. By considering all of these components and how they affect the final body plan, we hope to build a comprehensive picture of early embryonic morphogenesis.
 
Research Images:

Axolotl Neural plate

Xenopus Neural Plate

Xenopus neurula








 
Publications:
The Continuing Challenge of Understanding, Preventing, and Treating Neural Tube Defects (2013) Science 339, 1222002.
Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent (2012) PLoS Biology 10, e1001379.
Planar cell polarity acts through septins to control collective cell movement and ciliogenesis (2010) Science 329, 1337-1340.
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development. (2009) Nat Cell Biol 11, 1225-35.
Dishevelled controls apical docking and planar polarization of basal bodies in ciliated epithelial cells. (2008) Nat. Genet. 40, 871-9.
Developmental Regulation of Central Spindle Assembly and Cytokinesis during Vertebrate Embryogenesis (2008) Curr Biol 18, 116-123.
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling (2006) Nature Genetics 38, 303-311.

 
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