Christopher Jolly

Jolly, Christopher
Assistant Professor in Nutritional Sciences

E-mail: jolly@mail.utexas.edu

Website: http://www.utexas.edu/depts/he/Jolly.htm

Main Office: PAI 5.20A
Phone: 471-7290

Alternate Office: PAI 5.22
Phone: 471-7290

Mailing Address:
The University of Texas at Austin - ICMB
1 University Station A2700
103 E. 24th St.
Austin, TX 78712-1095
Research Summary:
   My lab focuses on understanding the biochemical/molecular mechanisms underlying reduced immune function in aging. We primarily focus on identifying signaling pathways which may lead to changes in lipid metabolism in T-lymphocytes. We are currently using two mouse knockout models. One is a cbl-b knockout mouse to examine the cbl-mediated protein ubiquitination pathway and protein kinase C signaling in young and old rodent models. We are also using this model to assess the role of the T-lymphocyte in colon and pancreatic cancer development. The second model is the GPAT knockout mouse in which phospholipid biosynthesis is reduced. We use this model to understand the role of increased cholesterol to phospholipid ratios in altered membrane lipid raft and lipid signalling in thymic development and peripheral T-lymphocyte function. Our main goal is to determine how these signaling pathways lead to age-dependent alterations in phospholipid metabolism. Ultimately, we hope to develop dietary and/or pharmacological strategies to delay or offset reduced immune function in the elderly.
 
Publications:
Is Dietary Restriction Beneficial for Human Health, such as for Immune Function? (2007) Curr Opin Lipidol 18, 53-57.
Aging Alters Phosphorylation Dependent Increases in Mitochondrial Glyerol-3-phosphate Acyltransferase 1 Activity in T-lymphocytes (2006) Biochem Biophys Acta: Molecular and Cell Biology of Lipids 1761, 129-139.
Diet Manipulation and Prevention in Aging, Cancer and Autoimmune Disease. (2005) Curr Opin Clin Nutr Metab Care 8, 382-387.
Dietary Flaxseed and Fish Oils Increase T-lymphocyte Acyl-CoA Binding Protein Expression and Phospholipid Mass (2005) Lipids 40, 81-87.
Aging reduces glycerol-3-phosphate acyltransferase activity in activated T-lymphocytes (2005) Biochem Biophys Acta: Molecular and Cell Biology of Lipids 1687, 164-172.
CD28 activation does not down regulate cbl-b expression in aged rat T-lymphocytes. (2004) Mech Aging Develop 125, 595-602.
Dietary restriction and immune function (2004) J. Ntr. 134, 1853-1856.
Aging and acyl-CoA binding protein alters mitochondrial glycerol-3-phosphate acyltransferase activity (2003) Biochem Biophys Acta: Molecular and Cell Biology of Lipids 1631, 12-16.
Lysophosphatidic acid acyltransferase activity is enhanced by albumin in T-lymphocyte membranes (2002) Lipids 37, 475-480.

 
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