Vishwanath Iyer

Iyer, Vishwanath
Associate Professor, MGM

E-mail: vishy@mail.utexas.edu

Website: http://www.iyerlab.org

Main Office: MBB 3.212AA
Phone: 232-7833

Mailing Address:
The University of Texas at Austin - ICMB
1 University Station A4800
2500 Speedway
Austin, TX 78712-1095
Research Summary:
   Nearly all cells respond to physiological or developmental cues by large-scale transcriptional reprogramming – altering the expression of hundreds to thousands of genes throughout the genome. Such sweeping changes in gene expression also underlie diseases such as cancer, and they can also be caused by normal or abnormal genetic variation between individuals. Our lab is interested in understanding how gene expression is regulated across a eukaryotic genome. We focus on regulation not only at the level of transcription, but also post-transcriptional regulation mediated by miRNAs. We work in human cells and also use yeast as a model system to address various questions regarding global gene regulation. We use molecular and genomic experimental methods such as microarrays and next-generation sequencing, coupled with computational analyses. Broad research areas in the lab include i) transcriptional regulatory networks in yeast during stress responses, ii) role of chromatin structure and remodeling in transcriptional regulation, iii) regulatory networks during human cell proliferation, iv) regulation and function of miRNAs during proliferation, v) relationship of transcription regulation with genetic variability among individuals.
 
Research Images:

Functional genomics with microarrays

 
Publications:
ArrayPlex: distributed, interactive and programmatic access to genome sequence, annotation, ontology, and analytical toolsets (2008) Genome Biol 12, R159.
Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation (2008) PLoS Biol 6, e65.
Stress-dependent dynamics of global chromatin remodeling in yeast: A dual role for SWI/SNF in the heat shock stress respons (2008) Mol Cell Biol 28, 2221-2234.
FAIRE (Formaldehyde Assisted Isolation of Regulatory Elements) isolates active regulatory elements from human chromatin (2007) Genome Research 6, 877-85.
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project (2007) Nature 447, 799-816.
Genetic reconstruction of a functional transcriptional regulatory network (2007) Nature Genetics 39, 683-687.
Mapping the chromosomal targets of STAT1 by Sequence Tag Analysis of Genomic Enrichment (STAGE) (2007) Genome Research 17, 910-916.
Genome-wide analysis of chromatin status using tiling microarrays (2007) Methods 41, 304-311.
PI3K signaling and miRNA expression during the response of quiescent human fibroblasts to distinct proliferative stimuli. (2006) Genome Biol. 7, R42.
Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. (2006) Proc Natl Acad Sci U S A. 103, 6368-6373.
Global role of TATA-box binding protein recruitment to promoters in mediating gene expression profiles (2004) Mol. Cell. Biol. 24, 8104-8112.
Genome-Wide Analysis of the Biology of Stress Responses through Heat Shock Transcription Factor (2004) Mol. Cell. Biol. 24, 5249-5256.
The Longhorn Array Database (LAD): An Open Source, MIAME compliant implementation of the Stanford Microarray Database (SMD) (2003) BMC Bioinformatics 4, 326-331.
Characterizing the physical genome (2002) Nature Genetics 32 suppl, 515-521.

 
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