David Hoffman

Hoffman, David
Associate Professor in Chemistry & Biochemistry

E-mail: dhoffman@mail.utexas.edu

Website: http://www.cm.utexas.edu/Faculty-and-Research/Faculty-Directory/Individual-Faculty-Pages/david_hoffman

Main Office: MBB 3.422FA
Phone: 471-7859

Mailing Address:
The University of Texas at Austin - ICMB
1 University Station A4800
2500 Speedway
Austin, TX 78712-1095

Graduate Students:

  • Lyon, Angeline

    • Research Summary:
       Biophysical methods such as nuclear magnetic resonance (NMR) spectroscopy and x-ray crystallography are extensively used in our investigations of protein and RNA structure and function. Current work includes the investigation of translation initiation factors, RNA binding proteins, and proteins involved in the synthesis and regulation of polyamines.
     
    Publications:
    Domain C of human poly-(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif. (2008) Biochemistry 47, 5804-5813.
    Crystal structure of spermidine/spermine N1-acetyltransferase in complex with spermine provides insights into substrate binding and catalysis. (2008) Biochemistry 47, 9145-9153.
    Structural characterization of a rigidified threading bisintercalator (2007) J Am Chem Soc 129, 1304-1311.
    The structure of eukaryotic translation initiation factor-4E from wheat reveals a novel disulfide bond (2007) Plant Physiol 143, 1504-1518.
    Solution structure of a conserved domain of antizyme: An enzyme regulator of polyamines. (2005) Biochemistry 44, 11777-11785.
    Crystal structure of the archaeal ribonuclease P protein aRpp29 from Archaeoglobus fulgidus (2004) Biochemistry 43, 14128-14138.
    The crystal structure of the N-terminal region of the alpha subunit of translation initiation factor 2 (eIF2a) from Saccharomyces cerevisiae provides a view of the loop containing serine-51, the site of phosphorylation by the eIF2a-specific kinases. (2003) J. Molecular Biology 334, 187-195.

     
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