Institute for Cellular and Molecular Biology at The University of Texas at Austin

Hackert, Marvin
Professor in Chemistry & Biochemistry
William Shive Centennial Professor In Biochemistry

Website: http://research.cm.utexas.edu/mhackert/

Main Office: WEL 5.266B
Phone: 471-1105

Mailing Address:
The University of Texas at Austin - ICMB
1 University Station A5300
105 E. 24th St.
Austin, TX 78712-1095

Research Summary:
Our research focuses on understanding function of proteins in relationship to their three-dimensional structures. Antizyme and antizyme inhibitor are regulatory proteins of ornithine decarboxylase that initiates polyamine biosynthesis. The structures of these proteins and their complexes are under investigation using X-ray crystallography, multidimensional NMR (with Dr. Hoffman), structural modeling, and other biophysical techniques. A collaborative project with Dr. Whitman involves the evolution of protein function and how a simple protein fold has been exploited to carry out a variety of different chemistries - tautomerization, decarboxylation and dehalogenation.

Publications:

Inactivation of the Phenylpyruvate Tautomerase Activity of Macrophage Migration Inhibitory Factor by 2-Oxo-4-phenyl-3-butynoate (2006) Bioorganic Chemistry 34, 183-99.

Evolution Consequences of Enzymatic Activity in the Tautomerase Superfamily: Mechanistic and of the L8R Mutation in 4-Oxalocrotonate Tautomerase (2006) Biochemistry 45, 7700-08.

Crystal Structures of the Wild-type, P1A Mutant, and Inactivated Malonate Semialdehyde Decarboxylase: A Structural Basis for the Decarboxylase and Hydratase Activities (2005) Biochemistry 44, 14818-27.

Solution Structure of a Conserved Domain of Antizyme: A Protein Regulator of Polyamines (2005) Biochemistry 44, 11777-85.

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