Andrea Gore

Gore, Andrea
Gustavus and Louise Pfeiffer Professor in Toxicology
Amer. Acad. for the Advancement of Science Fellow

E-mail: andrea.gore@mail.utexas.edu

Website: http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/gore.html

Main Office: PHR 5.218D
Phone: 512-471-3669

Alternate Office: ARC 0.226
Phone: 471-6311

Mailing Address:
The University of Texas at Austin
1 University Station A1915
2409 University Ave.
Austin, TX 78712-1095

Graduate Students:

  • Dickerson, Sarah
  • Naugle, Michelle
  • Walker, Deena
  • Wu, Di

    • Post Doc Students:

  • Chakraborty, Tandra
  • Daftary, Shabrine

    • Research Summary:
       My laboratory is interested in the mechanisms by which the brain controls reproductive development and aging. We are focusing on a group of neurons in the hypothalamus that synthesize and release a peptide, gonadotropin- releasing hormone (GnRH), that is the primary molecule controlling reproductive function throughout the life cycle. In order to better understand the mechanisms by which GnRH neurons change, and the central and peripheral factors that regulate GnRH neurons, we are characterizing changes in GnRH release, gene expression, neuroanatomy and physiology in normally developing male and female rats. We are also studying how perturbations of this system (e.g. by environmental toxicants, or by pharmacological agents acting on receptors on GnRH neurons) disrupt this process, resulting in aberrant reproductive processes. These experiments are intended to provide basic information about the neural mechanisms of normal reproduction, as well as to develop interventions to protect against environmental factors that may perturb normal reproductive development.
     
    Publications:
    NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiol. (2008) Neuroendocrinology 87, 129-41.
    Postpubertal decrease in hippocampal dendritic spines of female rats. (2008) Exp Neurol. 210, 339-48.
    Effects of perinatal polychlorinated biphenyls on adult female rat reproduction: development, reproductive physiology, and second generational effects. (2008) Biol Reprod 78, 1091-101.
    The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male rats. (2008) Neuroendocrinology 88, 95-102.
    Neuroendocrine systems as targets for environmental endocrine-disrupting chemicals. (2008) Fertil. Steril. 89, e101-2.
    Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems. (2008) Front Neuroendocrinol. 29, 358-74.
    Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle (2007) Reviews in Endocrine and Metabolic Disorders 8, 143-159.
    Transgenerational epigenetic imprints on mate preference (2007) Proc Natl Acad Sci USA 104, 5942-5946.
    Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals (2007) Exp Biol Med 232, 662-673.
    The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats (2007) Horm Behav 51, 364-372.
    Estrogen, menopause, and the aging brain: How basic neuroscience can inform hormone therapy in women (2006) J Neuroscience 26, 10332-10348.

     
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