Shawn Bratton

Bratton, Shawn
Associate Professor in Pharmacology and Toxicology

E-mail: sbbratton@mail.utexas.edu

Website: http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/bratton.html

Main Office: BME 3.510E
Phone: (512) 471-1735

Alternate Office: BME 4.506
Phone: (512) 471-2183

Mailing Address:
The University of Texas at Austin
1 University Station
College of Pharmacy, 107 West Dean Keeton
Austin, TX 78712

Graduate Students:

  • Mahajan, Indra
  • Schocken, John
  • Wible, Daric
  • Wu, Chu-Chiao
  • Yang, Kuei-Ting
  • Yeh, Ting-Chun

    • Research Summary:
       My laboratory focuses primarily on basic mechanisms of apoptosis (programmed cell death) and autophagy (self-cannibalism) in the context of cancer.
     
    Publications:
    DARK apoptosome secrets come to light (2011) Structure 19, 4-6.
    Regulation of the Apaf-1-caspase-9 apoptosome (2010) J. Cell Sci. 123, 3209-3214.
    TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1 (2010) Cell Death Differ. 17, 1288-1301.
    The Apaf-1•pro-caspase-9 apoptosome complex functions as a proteolytic-based molecular timer (2009) EMBO J. 28, 1916-1925.
    The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspases-3 and -7 via unique mechanisms at distinct steps in their processing (2009) J. Biol. Chem. 284, 12772-12782.
    'Heated' debates in apoptosis (2007) Cell Mol. Life Sci. 64, 2329-2333.
    Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease (2007) EMBO J. 26, 3144-3156.
    XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders (2006) Mol. Cell 21, 775-785.
    Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting the apoptosome (2006) Cell 125, 1333-1346.
    Heat shock induces apoptosis independently of any known initiator caspase-activating complex (2006) J. Biol. Chem. 281, 16991-17000.

     
    Search PubMed for more publications by Prof. Name
    (a new browser window will open)
    "Caution, this search may require more information to be accurate or specific. Check authors and institution carefully."

    Max Docs:  Pub. Date limit: