Shawn Bratton

Bratton, Shawn
Associate Professor in Pharmacology and Toxicology

E-mail: sbbratton@mail.utexas.edu

Website: http://www.utexas.edu/pharmacy/divisions/pharmtox/faculty/bratton.html

Main Office: PHR 5.218A
Phone: (512) 471-1735

Alternate Office: PHR 6.210/6.218
Phone: (512) 471-5098

Mailing Address:
The University of Texas at Austin
1 University Station
College of Pharmacy, 2409 University Ave.
Austin, TX 78712-0215
Research Summary:
   My laboratory focuses primarily on basic mechanisms of apoptosis (programmed cell death) and autophagy (self-cannibalism) in the context of cancer.
 
Publications:
The Apaf-1•pro-caspase-9 apoptosome complex functions as a proteolytic-based molecular timer (2009) EMBO J. 28, 1916-1925.
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspases-3 and -7 via unique mechanisms at distinct steps in their processing (2009) J. Biol. Chem. 284, 12772-12782.
'Heated' debates in apoptosis (2007) Cell Mol. Life Sci. 64, 2329-2333.
Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease (2007) EMBO J. 26, 3144-3156.
XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders (2006) Mol. Cell 21, 775-785.
Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting the apoptosome (2006) Cell 125, 1333-1346.
Heat shock induces apoptosis independently of any known initiator caspase-activating complex (2006) J. Biol. Chem. 281, 16991-17000.

 
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