Shawn Bratton

Bratton, Shawn
Associate Professor in Pharmacology and Toxicology



Main Office: BME 3.510E
Phone: (512) 471-1735

Alternate Office: BME 4.506
Phone: (512) 471-2183

Mailing Address:
The University of Texas at Austin
1 University Station
College of Pharmacy, 107 West Dean Keeton
Austin, TX 78712

Graduate Students:

  • Mahajan, Indra
  • Schocken, John
  • Wible, Daric
  • Wu, Chu-Chiao
  • Yang, Kuei-Ting
  • Yeh, Ting-Chun

  • Research Summary:
       My laboratory focuses primarily on basic mechanisms of apoptosis (programmed cell death) and autophagy (self-cannibalism) in the context of cancer.
    DARK apoptosome secrets come to light (2011) Structure 19, 4-6.
    Regulation of the Apaf-1-caspase-9 apoptosome (2010) J. Cell Sci. 123, 3209-3214.
    TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1 (2010) Cell Death Differ. 17, 1288-1301.
    The Apaf-1•pro-caspase-9 apoptosome complex functions as a proteolytic-based molecular timer (2009) EMBO J. 28, 1916-1925.
    The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspases-3 and -7 via unique mechanisms at distinct steps in their processing (2009) J. Biol. Chem. 284, 12772-12782.
    'Heated' debates in apoptosis (2007) Cell Mol. Life Sci. 64, 2329-2333.
    Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease (2007) EMBO J. 26, 3144-3156.
    XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders (2006) Mol. Cell 21, 775-785.
    Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting the apoptosome (2006) Cell 125, 1333-1346.
    Heat shock induces apoptosis independently of any known initiator caspase-activating complex (2006) J. Biol. Chem. 281, 16991-17000.

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