Faculty
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Anslyn, Eric V.
Distinguished Teaching Professor in Chemistry & Biochemistry
Norman Hackerman Professorship in Chemistry
E-mail Website Main Office: WEL 5.201
Phone: 471-0068 Alternate Office: WEL 5.314
Phone: (512) 471-3239 Mailing Address:
The University of Texas at Austin - ICMB
1 University Station A5300
105 E. 24th St.
Austin, TX 78712-1095
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Research Summary:
Our research is oriented at developing artificial enzymes and sensors by synthetic and combinatorial library methods.
Our synthetic projects are targeted to phosphodiester hydrolysis, enolate alkylations, and polysaccharide cleavage.
The combinatorial library projects are focused on forming abiotic secondary structure via hydrogen bonding in polythioureas, and polyguanidiniums. In each synthetic project, natural systems such as enzymes and transport proteins are carefully examined, and mimics are designed with the aid of computer modeling. The mimics are evaluated
as to their success at performing the desired catalytic or sensing event, and then redesigned for optimization. In each combinatorial library project, solid phase synthesis of novel polymers are pursued incorporating scaffolds the create binding cavities and specific molecular recognition events. The novel polymers are tested for binding, catalysis,
and sensing functions by screening the libraries for activity.
Publications:| 2007 | Wright AT, Edwards NY, Anslyn EV, McDevitt JT, The discriminatory power of differential receptor arrays is improved by prescreening-a demonstration in the analysis of tachykinins and similar peptides, Angew Chem Int Ed Engl 46:8212-8215. | | 2007 | Edwards NY, Sager TW, McDevitt JT, Anslyn EV, Boronic acid based peptidic receptors for pattern-based saccharide sensing in neutral aqueous media, an application in real-life samples, J Am Chem Soc 129:13575-13583. | | 2007 | Collins BE, Anslyn EV, Pattern-based peptide recognition, Chemistry 13:4700-4708. | | 2006 | Folmer-Andersen JF, Kitamura M, Anslyn EV, Pattern-based discrimination of enantiomeric and structurally similar amino acids: an optical mimic of the mammalian taste response, J Am Chem Soc 128:5652-5653. |
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