Sibum Sung

Sung, Sibum
Assistant Professor Cell and Developmental Biology



Main Office: NMS 5.110
Phone: 512-232-0867

Alternate Office: NMS 5.268
Phone: 232-4196

Mailing Address:
2506 Speedway, NMS 3.316/5.110
1 University station A5000
Austin, TX 78712

Research Summary:

Our research interests focus on the genetic, molecular and biochemical understandings of plant development through plant-environment interactions. We are particularly interested in the epigenetic regulation of the floral transition by environmental cues, such as temperature and photoperiod. The prolonged cold of winter, known as vernalization, is one such cue that certain plants use to acquire competence to flower the following spring. In Arabidopsis, vernalization results in the mitotically stable repression of the potent floral repressor, FLOWERING LOCUS C (FLC). The molecular nature of this environmentally-induced epigenetic change has been a fascinating question in plant biology. We have shown that the series of Histone modifications are involved in the epigenetic repression of FLC by vernalization. Furthermore, the diversity of Histone modifications that are related with vernalization-mediated epigenetic changes suggests that FLC chromatin could be used for the model system to study Histone biology in plants. We would like to use this environmentally-induced epigenetic switch as a model system to study chromatin remodeling in eukaryotes.

2013Kim D.-H. and S. Sung, Coordination of the vernalization response through a VIN3 and FLC gene family regulatory network in Arabidopsis, Plant Cell Feb 15:Epub ahead of print view.
2013Hyun, Y., H. Yun, K. Park, H. Ohr, O. Lee, D. H. Kim, S. Sung and Y. Choi, The catalytic subunit of Arabidopsis DNA polymerase α ensures stable maintenance of histone modification., Development 140:156-66 view.
2012Sung S, E. Huq and Z. J. Chen, International plant molecular biology: a bright future for green science., Genome Biol. 13:323 view.
2012Zografos B. R. and S. Sung, Vernalization-mediated chromatin changes., J Exp Bot. 63:4343-8 view.
2012Heo J. B., S. Sung, S. Assmann, Ca2+-dependent GTPase, extra-large G protein 2 (XLG2), promotes activation of DNA-binding protein related to vernalization 1 (RTV1), leading to activation of floral integrator genes and early flowering in Arabidopsis., J Biol Chem. 287:8242-53 view.
2012Kim D. H. and S. Sung, Environmentally coordinated epigenetic silencing of FLC by protein and long noncoding RNA components., Curr Opin Plant Biol. 15:51-6 view.
2012Kim E. D. and S. Sung, Long noncoding RNA: unveiling hidden layer of gene regulatory networks., Trends Plant Sci. 17:16-21 view.
2011Heo J. B. and S. Sung, Encoding memory of winter by noncoding RNAs., Epigenetics 6:544-7 view.
2011Heo J. B. and S. Sung, Vernalization-mediated epigenetic silencing by a long intronic noncoding RNA, Science 331:76-9 view.
2010Kim D. H. and S. Sung, Role of VIN3-LIKE 2 in facultative photoperiodic flowering response in Arabidopsis., Plant Signal Behav. 5:12 view.
2010Kim D. H., B.R. Zografos, and S. Sung, Mechanisms underlying vernalization-mediated VIN3 induction in Arabidopsis., Plant Signal Behav. 5:11 view.
2010Kim D. H. and S. Sung, The Plant Homeo Domain finger protein, VIN3-LIKE 2, is necessary for photoperiod-mediated epigenetic regulation of the floral repressor, MAF5, Proc. Natl. Acad. Sci. U S A 107:17029-34 view.
2010Kim D. H., B.R. Zografos, and S. Sung, Vernalization-mediated VIN3 induction overcomes the LIKE-HETEROCHROMATIN PROTEIN 1/Polycomb Repression Complex 2 -mediated epigenetic repression., Plant Physiol. 154:949-957 view.
2010Horvath D. P., S. Sung, D.-H. Kim, W. Chao, and J. V. Anderson, Characterization, expression and function of DORMANCY ASSOCIATED MADS-BOX genes from leafy spurge, Plant Mol. Bio. 73:169-179 view.
2009Kim, D.-H., M. Doyle, S. Sung, and R. M. Amasino, VERNALIZATION: WINTER AND THE TIMING OF FLOWERING IN PLANTS., Annual Rev. Cell Dev. Biol. 25:277-299 view.
2008Schmitz, R.J., Sung, S., Amasino, R.M., Histone arginine methylation is required for vernalization-induced epigenetic silencing of FLC in winter-annual Arabidopsis thaliana, Proc. Natl. Acad. Sci. U S A 105:411-416 view.
2006Sung S. , He, Y. ,Eshoo, T. W. , Tamada, Y. ,Johnson, L. ,Nakahigashi, K. , Goto, K. , Jacobsen, S. E. and Amasino, R. M. , Epigenetic maintenance of the vernalized state in Arabidopsis thaliana requires LIKE HETEROCHROMATIN PROTEIN 1, Nature Genetics 38:706-710 view.
2006Sung S. , Schmitz, R. and Amasino, R. M., A PHD finger protein involved in both the vernalization and photoperiod pathways in Arabidopsis, Genes and Development 20:3244-3248 view.
2005Sung, S. and Amasino, R. M., To remember winter: Towards a molecular understanding of vernalization, Annual Rev. Plant Biol. 56:491-508 view.
2004Sung, S. and R. M. Amasino, Vernalization and epigenetics: how plants remember winter, Curr. Op. in Plant Biol. 7:4-10 view.
2004Sung, S. and Amasino, R. M. , Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3, Nature 427:159-164 view.

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