Faculty
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Alper, Hal
Assistant Professor
E-mail Website Main Office: CPE 5.408
Phone: 512-471-4417 Mailing Address:
1 University Station
CPE 5.408
Austin, TX 78712
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Research Summary:
The goal of metabolic and cellular engineering is to endow novel and useful properties to cellular systems. Recent advances in molecular biology and genetic engineering empower metabolic engineers with an increasing ability to create any desired cellular modification. The integration of these approaches with an ever-increasing database of knowledge about these cellular systems (due in part to genomic sequencing efforts) provides an unprecedented opportunity to engineer cellular systems. Our research group focuses on the integration and implementation of these tools and knowledge for the design, production, and elicitation of phenotypes relevant to biotechnological processes and medical interest.
Using a variety of host systems including microbial (eg. Escherichia coli), fungal (eg. yeast), and mammalian (eg. Chinese Hamster Ovary (CHO) cells), we seek to develop the necessary genetic tools and methodologies for creating industrially-relevant organisms for biomolecules, biofuels, and biopharmaceuticals. To accomplish this task, traditional pathway engineering will be utilized in conjunction with novel tools for introducing genetic control (such as global Transcription Machinery Engineering, promoter libraries, and gene mutagenesis).
Publications:| 2007 | Hal Alper and Gregory Stephanopoulos, Global transcription machinery engineering: a new approach for improving cellular phenotype, Metabolic Engineering 9:258-267. | | 2006 | Hal Alper, Joel Moxley, Elke Nevoigt, Gerald Fink, and Gregory Stephanopoulos, Engineering yeast transcription machinery for improved ethanol tolerance and production, Science 314:1565 - 1568. | | 2005 | Hal Alper, Yong-su Jin, J. Moxley, and G. Stephanopoulos, Identifying gene targets for the metabolic engineering of Escherichia coli, Metabolic Engineering 7:155-164. | | 2005 | Hal Alper, Curt Fischer, Elke Nevoigt, and Gregory Stephanopoulos, Tuning Genetic Control through Promoter Engineering, PNAS 102:12678-12683. | | 2005 | Hal Alper, Kohei Miyaoku, and Gregory Stephanopoulos, Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets, Nature Biotechnology 23:612 - 616. |
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