Jeffrey Gross

Gross, Jeffrey
Associate Professor in Molecular Cell & Developmental Biology
Chair, Cell & Molecular Biology GSC



Main Office: PAT 206
Phone: 471-1518

Alternate Office: PAT 208
Phone: 471-4414

Mailing Address:
The University of Texas at Austin
1 University Station
Austin, TX 78712-0195

Research Lab Students:
    Graduate Student
  • Hanovice, Nicholas - Graduate Student
  • Koenig, Kristen - Graduate Student
  • Seritrakul, Pawat - Graduate Student
    Post Doctoral
  • Hartsock, Andrea - Post Doctoral
  • Lee, Jiwoon - Post Doctoral
  • Lee, Chan Jae - Post Doctoral
  • Shoemaker-Daly, Christina - Post Doctoral
  • Tittle, Rachel - Post Doctoral
  • Hayes, Julie - Staff
  • Minowa, Ryoko - Staff
  • Nuckels, Richard - Staff

  • Research Summary:

    Our research focuses on vertebrate eye development utilizing the zebrafish as a model system. Combining forward genetic screens with reverse genetic and embryological manipulations we hope to understand the molecular, cellular and developmental events that regulate eye formation and visual function. Current areas of interest in the lab include studies focusing on the development and maintenance of the lens, retina, hyaloid vasculature and retinal pigmented epithelium of the eye, and elucidation of the molecular and cellular mechanisms that regulate ocular morphogenesis. Our research combines molecular, cellular, biochemical, transgenic and in vivo imaging techniques to address these questions. It is our hope that these studies will ultimately lead to a better understanding of visual system disorders such as macular degeneration, cataracts and ocular colobomas that often result in blindness in afflicted patients. Finally, we also have an interest in evolution of the eye and have recently initiated studies of eye development in squid to address this topic.

    2013Daly CMS, Willer J, Gregg R and JM Gross , snow white – a zebrafish mode of Hermansky-Pudlak Syndrome Type 5, Genetics in press:.
    2013Lee J, Lee BK and JM Gross , Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata, Human Molecular Genetics 22(17):3568-82.
    2012Luo J, Uribe RA, Hayton S, Calinescu A, Gross JM, PF Hitchcock , Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina, Neural Development 7(1):33.
    2012Lee J, Cox BD, Daly C, Lee C, Nuckels RJ, Tittle RK, Uribe RA and JM Gross , An ENU mutagenesis screen in zebrafish for visual system mutants identifies a novel splice-acceptor site mutation in patched2 that results in colobomas, Investigative Ophthalmology and Visual Science 53(13):8214-21.
    2012Hayes J, Napier H, Link BA and JM Gross , Integrin alpha5/Fibronectin and Focal adhesion kinase are required for normal lens development in zebrafish, Molecular Biology of the Cell 23 (24):4725-38.
    2012Uribe RA, Kwon T, Marcotte EM, JM Gross , Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis, Developmental Biology 371:280-292 .
    2011Bibliowicz J, Gross JM., Ectopic proliferation contributes to retinal dysplasia in the juvenile zebrafish patched2 mutant eye., Investigative Ophthalmology and Visual Science 52(12):8868-77.
    2011Bibliowicz J, Tittle RK and JM Gross , Towards a better understanding of human eye disease: insights from the zebrafish, Danio rerio, Progress in Nucleic Acid Research and Molecular Biology 100:287-330.
    2011Rachel K. Tittle, Ryan Sze, Anthony Ng, Richard J. Nuckels, Mary E. Swartz, Ryan Anderson, Justin Bosch, Didier Y.R. Stainier, Johann K. Eberhart and Jeffrey M. Gross, Uhrf1 and Dnmt1 are required for zebrafish lens development, Developmental Biology 350:50-63.
    2010Uribe, RA and JM Gross, Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics, Development 137:3763-3774.
    2009Bibliowicz J. and JM Gross, Expanded progenitor populations, vitreo-retinal abnormalities, and Müller glial reactivity in the zebrafish leprechaun/patched2 retina, BMC Developmental Biology 9:52.
    2009Ng A, Uribe RA, Yieh L, Nuckels R and JM Gross, Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development, Development 136(15):2601-11.
    2009Nuckels RJ, Ng A, Darland T and JM Gross , The Vacuolar-ATPase Complex Regulates Retinoblast Proliferation and Survival, Photoreceptor Morphogenesis and Pigmentation in the Zebrafish Eye, Investigative Ophthalmology and Visual Science 50:893-905.
    2009Brown JD, Dutta S, Bharti K, Bonner RF, Munson PJ, Dawid IB, Akhtar AL, Onojafe IF, Alur RP, Gross JM, Hejtmancik JF, Jiao X, Chan WY, Brooks BP , Expression profiling during optic fissure closure identifies two Nlz genes with a critical role in fissure closure, Proceedings of the National Academy of Sciences 106:1462-7.
    2008Lee J, Willer J, Willer GB, Smith K, Gregg R and JM Gross , Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye, Developmental Biology 319:10-22.
    2007Lee J. and JM Gross, Laminin Beta 1 and Gamma 1 Containing Laminins are Essential for Basement Membrane Integrity in the Zebrafish Eye, Investigative Ophthalmology and Visual Science 48:2483-2490.
    2006Fairbank P, Lee C, Ellis A, Hildebrand JH, Gross JM and JB Wallingford , Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium, Development 133:4109-4118 .

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