Faculty
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Bull, James J.
Johann Friedrich Miescher Regents Professor in Molecular Biology
E-mail Website Main Office: PAT 131
Phone: 471-8266 Alternate Office: PAT 128-138
Phone: (512) 471-5661 Mailing Address:
The University of Texas at Austin - ICMB
1 University Station C0930
2415 Speedway
Austin, TX 78712-1095
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Research Lab Students:Brown, SamHarcombe, WilliamHeineman, RichardSpringman, Rachael
Research Summary:
see section bio for more info
Evolutionary genetics from the molecular to the phenotypic levels comprises the bulk of my research. Specific topics include the evolution of virulence, evolutionary robustness and redundancy, the genetic basis of adaptation, and phylogeny reconstruction. Experimental systems are developed in which evolution occurs over short time periods in the laboratory; the evolved lines are then analyzed at the molecular genetic level, so that the course of evolution is known with certainty. Research organisms are chiefly bacteriophage, enabling complete genome sequencing. Students are encouraged to initiate
their research on a well-defined model system to gain experience and then expand their research to problems of their own design.
Publications:| 2008 | Crews D, Bull JJ, Sex determination: some like it hot (and some don't), Nature 451:527-528. | | 2007 | Holloway AK, Palzkill T, Bull JJ, Experimental evolution of gene duplicates in a bacterial plasmid model, J Mol Evol 64:15-22. | | 2007 | Heineman RH, Bull JJ, Testing optimality with experimental evolution: lysis time in a bacteriophage, Evolution Int J Org Evolution 61:1695-1709. | | 2006 | Bull JJ, Regoes RR, Pharmacodynamics of non-replicating viruses, bacteriocins and lysins, Proc Biol Sci 273:2703-2712. |
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