Faculty

John Sisson

Sisson, John
Associate Professor in Molecular Cell & Developmental Biology

E-mail

Website

Main Office: PAT 219
Phone: 475-7561

Alternate Office: PAT 216
Phone: 475-7562

Mailing Address:
The University of Texas at Austin
One University Station, C1000
Patterson Labs
Austin, TX 78712-0253
Research Lab Students:
  • Monzo, Kate
  • Wang, Howard

    • Research Summary:

    The Sisson lab is interested in the molecular mechanisms that control how cells form and differentiate in early animal embryos. Our research is currently focused on elucidating the molecular mechanisms of two processes that control the formation of the first polarized epithelial cell layer in early Drosophila embryos: Golgi-dependent membrane secretion and Fragile X mental retardation protein-dependent translational regulation. We study these processes using an integrated experimental approach that combines the advantages of biochemistry, genetics, molecular biology and live embryo imaging.
    Research Images:

    - Drosophila cleavage furrow formation depends on microtubules (green) and membrane secretion from an array of Golgi bodies (red).

    - Temperature sensitive (ts) mutations are helping us understand the molecular mechanisms controlling cleavage furrow formation and cell polarity.

     
    Publications:
    2007Dagani, G. T., Monzo, K., Fakhoury, J. R., Chen, C. C., Sisson, J. C., and X. Zhang , Microfluidic self-assembly of live Drosophila embryos for versatile high-throughput analysis of embryonic morphogenesis, Biomedical Microdevices 9:681-694.
    2006Monzo, K., Papoulas O., Cantin, G.T., Wang, Y., Yates, J.R., and J.C. Sisson, Fragile X mental retardation protein controls trailer hitch expression and cleavage furrow formation in Drosophila embryos, The Proceedings of the National Academy of Sciences 103:18160-18165.
    2005Zarnescu, D., Jin, P., Betschinger, J., Nakamoto, M., Wang, Y., Dockendorff, T., Feng, Y., Jongens, T., Sisson, J. C., Knoblich, J., Warren, S., and K. Moses , Fragile X protein functions with Lgl and the PAR complex in flies and mice, Developmental Cell 8:43-52.
    2005Papoulas, O, Hays, T.S., and J.C. Sisson, The golgin Lava Lamp mediates dynein-based Golgi movements during Drosophila cellularization, Nature Cell Biology 7:612-618.
    2005Beronja, S., Laprise, P., Papoulas, O., Pellikka, M., Sisson, J. C., and U. Tepass, Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells, The Journal of Cell Biology 169:635-646.

     
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