Faculty

Payne, Shelley
Professor of Molecular Genetics & Microbiology
University Distinguished Teaching Professor

E-mail

Website

Main Office: NMS 2.124
Phone: (512) 471-9258

Alternate Office: NMS 2.246
Phone: (512) 471-5204

Mailing Address:
THE UNIVERSITY OF TEXAS AT AUSTIN
Section of Molecular Genetics and Microbiology
2506 Speedway Stop A5000
Austin, TX 78712-1191

Graduate Student

• Boulette, Megan - Graduate Student
• Coughlin, Laura - Graduate Student
• Craig, Stephanie - Graduate Student
• Gore, Aja - Graduate Student
• Helton, Emily - Graduate Student
• Ma, Li - Graduate Student
• Marman, Hannah - Graduate Student
• Morrison, Rebecca - Graduate Student
• Oglesby, Amanda - Graduate Student
• Sharma, Ashima - Graduate Student

Post Doctoral

• Carpenter, Chandra - Post Doctoral
• Waligora, Elizabeth - Post Doctoral

Staff

• Fisher, Carolyn - Staff
• Mey, Alexandra - Staff
• Wyckoff, Elizabeth - Staff



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Research Summary:

We are interested in the genetics and regulation of virulence factors of gram negative pathogens, including Shigella and Vibrio cholerae. Members of the Shigella species are found both extracellularly and intracellularly within the host, and distinct sets of genes are expressed in each of these environments. We are studying bacterial gene expression in vivo by a variety of molecular and microscopic techniques, and we have identified genes that are required for growth in the intracellular environment of the host. Bacterial genes found to be important for growth and survival in vivo include those that encode components of iron transport systems, metabolic pathways and cell surface proteins.


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Publications:

2011	Be'er A, Florin EL, Fisher CR, Swinney HL, Payne SM, Surviving Bacterial Sibling Rivalry: Inducible and Reversible Phenotypic Switching in Paenibacillus dendritiformis, MBio 2:e00069-11 view.
2010	Gore, A.L. and S.M. Payne, CsrA and Cra influence Shigella flexneri pathogenesis, Infect. Immun 78:4674-4682 view.
2010	Be'er A., G. Ariel, O Kalisman, Y. Helman, A. Sirota-Madi, H.P. Zhang, E. L. Florin, S. M. Payne, E. Ben-Jacob and H. L. Swinney, Lethal protein produced in response to competition between sibling bacterial colonies, Proc Natl Acad Sci USA view.
2009	Be'er A., R.S. Smith, H. P. Zhang, E. L. Florin, S. M. Payne and H. L. Swinney, Paenibacillus dendritiformis bacterial colony growth depends on surfactant but not on bacterial motion, J. Bacteriology 191:5758-5764 view.
2009	Roux, A., S. M. Payne, and M. S. Gilmore, Microbial Telesensing: Probing the environment for friends, foes and food from a distance, Cell Host Microbe 6:119-124 view.
2009	Fisher C.R., Davies N.M., Wyckoff E.E., Feng Z., Oaks E.V., Payne S.M., Genetics and virulence association of the Shigella flexneri sit iron transport system, Infect. Immun. 77:1992-1999.
2009	Wyckoff E.E., Boulette M.L., Payne S.M., Genetics and environmental regulation of Shigella iron transport systems, Biometals 22:43-51 view.
2009	Be'er A., Zhang H.P., Florin E.L., Payne S.M., Ben-Jacob E., Swinney H.L., Deadly competition between sibling bacterial colonies, Proc Natl Acad Sci U S A 106:428-433 view.
2008	Mey A.R., Wyckoff E.E., Hoover L.A., Fisher C.R., Payne S.M., Vibrio cholerae VciB promotes iron uptake via ferrous iron transporters, J. Bacteriology 190:5953-5962 view.
2007	Boulette, M.L. and S.M. Payne, Anaerobic regulation of Shigella flexneri virulence:ArcA regulates fur and iron acquisition genes, J. Bacteriology 189:6957-6967 view.
2007	Wyckoff, E.E., A.R. Mey and S.M. Payne, Iron acquisition in Vibrio cholerae, Biometals 20:405-416 view.
2007	Kresse A. U., I. Reinacker, A.M. Valle, H. Steinruck, H. Claus, S.M. Payne, H. Tschape, P.H. Williams, R. Reissbrodt, Enterohaemorrhagic Escherichia coli O157 and non- 0157 serovars differ in their mechanisms for iron supply, Int. J. Med. Microbiol. 297:9-158.
2007	Bhadra, S., M. Lozano, S. M. Payne, and J. P. Dudley, A Unique Mechanism of Resistance to Viral and Bacterial Pathogens, PLoS Pathogens 2:e128 view.
2007	Murphy, E.R. and S. M. Payne, RyhB, an iron-responsive small RNA, regulates Shigella virulence , Infect. immun. 75:3470-3477 view.
2007	Purdy, G., C. Fisher and S. M. Payne, IcsA surface presentation in S. flexneri requires the periplasmic chaperones DegP, Skp and SurA, J. Bacteriol. 189:5566-5573 view.
2006	Payne SM, Wyckoff EE, Murphy ER, Oglesby AG, Boulette M, and Davies N., Iron and pathogenesis of Shigella: iron acquisition in the intracellular environment, Biometals 19:173-180 view.
2006	Wycoff, E.E., A.R. Mey, A. Leimbach, C.F. Fisher and S.M. Payne, Characterization of ferric and ferrous iron transport systems in Vibrio Cholerae, J. Bact. 188:6515-6523 view.
2006	Sharma, A.K. and S. M. Payne, Induction of expression of hfq by DksA is essential for Shigella flexneri virulence, Mol. MIcrobiol. 62:463-479 view.
2005	Runyen-Janecky L.J., A. M. Boyle, A. Kizzee, L. Liefer, S. M. Payne, Role of the Pst system in plaque formation by the intracellular pathogen Shigella flexneri, Infect. Immun. 73:1404-1410 view.
2005	Mey, A. R., E. E. Wyckoff, V. Kanukurthy, C. R. Fisher and S. M. Payne, Iron and Fur regulation in Vibrio cholerae and the role of Fur in virulence, Infect. Immun. 73:8167-8178 view.
2005	Oglesby, A. G., E. R. Murphy, V. R. Iyer, and S. M. Payne, Fur regulates acid resistance in Shigella flexneri via RyhB and ydeP, Mol. Microbiol. 58:1354-1367 view.
2005	Mey, A. R., S. A. Craig, and S. M. Payne, Characterization of V. cholerae RyhB: the RyhB regulon and the role of ryhB in biofilm formation, Infect. Immun. 73:5706-5719 view.
2004	Wyckoff, E.E., M. Schmitt, A., Wilks, S.M. Payne, HutZ is required for efficient heme utilization in Vibrio cholerae, J. Bacteriol. 186:4142-4151 view.
2003	Wei, J., et al., Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T, Infect. Immun. 71:2775-2786 view.