Alan Lloyd

Lloyd, Alan
Professor in Molecular Cell & Developmental Biology


Main Office: MBB 1.448BA
Phone: 471-3530

Mailing Address:
The University of Texas at Austin - ICMB
1 University Station A4800
2500 Speedway
Austin, TX 78712-1095

Research Summary:

The main goal of my lab is to understand developmental mechanisms and pigment pathways in plants. The control of cell fate decisions is a central issue during plant development and pattern formation. One main focus of my lab is to use trichome (epidermal plant hair) initiation as a simple and amenable model to study the control of plant cell fate decision events. Over the years we have identified a combinatorial transcriptional complex that regulates trichome initiation and patterning. We are studying how this complex functions by manipulating the complex members and by investigating many of the complex's transcriptional targets. This complex also has pleiotropic control of the common red/purple anthocyanin pigment pathway in Arabidopsis and most other flowering plants. We have studied how the complex regulates these pigments and recently we have begun work on a red pigment pathway, the betalains, that are narrowly restricted to a single order of flowering plants that include beets, cactus and other taxa. The betalain pathway is much simpler than the anthocyanin pathway and has the potential to be used as a color and fluorescent marker in heterologous systems, fungi, animals and others.

We have performed Next Generation Roche 454 transcriptome sequencing of hypocotyl mRNA from Table Beet and Amaranthus cruentus. Both of these tissues produce large amounts of betalain pigments. Contig sequences are contained in Word files and Excel files contain BLAST annotation information that can be downloaded here.

Amaranthus cruentus 454 annotation

Amaranthus contig sequences

Table beet 454 annotation

Table beet contig sequences

2009Gonzalez A, Mendenhall J, Huo Y, Lloyd AM, TTG1 complex MYBs, MYB5 and TT2, control outer seed coat differentiation., Developmental Biology 325:412-421.
2008Zhao M, Morohashi K, Hatlestad G, Grotewold E, Lloyd AM, The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci., Development 135:1991-1999.
2007Morohashi K, Zhao M, Yang M, Read B, Lloyd AM, Lamb R, Grotewold E, Participation of the Arabidopsis bHLH Factor GL3 in Trichome Initiation Regulatory Events, Plant Physiology 145:736-746.
2005Symonds VV, Godoy V, Alconanda T, Botto J, Juenger T, Casal J, Lloyd AM, Mapping quantitative trait loci in multiple populations of Arabidopsis thaliana identifies natural allelic variation for trichome density, Genetics 169:1649-1658.
2003Zhang F, Gonzalez A, Zhao M, Payne CT, Lloyd AM, A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis, Development 130:4859-4869.

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