Liu, Hung-wen (Ben)
George H. Hitchings Regents Chair In Drug Design
Professor of Medicinal Chemistry, Chemistry, and Biochemistry
Main Office: PHR 3.206B
Alternate Office: PHR 4th floor
The University of Texas at Austin, PHAR-MED CHEM
1 University Station A1935
2409 University Ave.
Austin, TX 78712-1095
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Research Lab Students:
- Chen, Wei-chen - Graduate Student
- Kim, Hak Joong - Graduate Student
- Sasaki, Eita - Graduate Student
- Thibodeaux, Christopher - Graduate Student
- White, Jessica - Graduate Student
- Liu, Yung-nan - Post Doctoral
- Ogasawara, Yasushi - Post Doctoral
My group is currently working on three general areas with the focus aimed at the elucidation of the mechanisms of novel enzymatic reactions and the design of methods to control and/or regulate their functions. Most of the biological
systems under investigation are target candidates for therapeutic drugs.
Enzyme Mechanism and Inhibitor Design: We study the mechanisms of enzymes involved in diverse biological processes including the formation of bacterial cell wall, biosynthesis of and resistance to antibiotics, and biosynthesis
and metabolism of lipids.
Metabolic Pathway Engineering: Through selective disruption and/or substitution of sugar biosynthetic genes in the microorganisms that produce bioactive glycosylated
secondary metabolites, we are exploring the feasibility
of engineering nature´┐Żs biosynthetic machinery for the production of novel compounds carrying designed sugar appendages.
Protein Function Regulation: We study poly(ADP-ribose) polymerase, an enzyme that recognizes damaged DNA and turns on the repairing machinery through polyADP-ribosylation
of itself and other nuclear proteins. This posttranslational
modification is also essential to other crucial cellular events including apoptosis.
|2011||Kim, H. J.; Ruszczycky, M. W.; Choi, S. H.; Liu, Y.-n.; Liu, H.-w., An Enzyme-Catalyzed [4+2] Cycloaddition is a Key Step in the Biosynthesis of Spinosyn A, Nature 473:109-112.|
|2010||Sasaki, E.; Ogasawara, Y.; Liu, H.-w. , A Biosynthetic Pathway for BE-7585A: A 2- Thiosugar-containing Augucycline-type Natural Product, J. Am. Chem. Soc. 132:7405-7417.|
|2010||Ruszczycky, M. W.; Choi, S. H.; Liu, H.-w., Stoichiometry of the Redox Neutral Deamination and Oxidative Dehydrogenation Reactions Catalyzed by the Radical SAM Enzyme DesII, J. Am. Chem. Soc. 132:2359-2369.|
|2009||Munos, J. W.; Pu, X.; Mansoorabadi, S. O.; Kim, H. J.; Liu, H.-w. , A Secondary Kinetic Isotope Effect Study of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase-catalyzed Reaction: Evidence for a Retroaldol-Aldol Rearrangement, J. Am. Chem. Soc. 131:2048-2049.|
|2008||Thibodeaux, C. J.; Melancon, C. E., III.; Liu, H.-w. , Natural Product Sugar Biosynthesis and Enzymatic Glycodiversification, Angew. Chem. Int. Ed. 47:9814-9859.|
|2008||Tao, Z.; Gao, P.; Hofmann, D.; Liu, H.-w. , Domain C of Human Poly(ADP-ribose) Polymerase-1 is Important for Enzyme Activity and Contains a Novel Zinc-Ribbon Motif, Biochemistry 47:5804-5813.|
|2007||Thibodeaux, C.; Melanšon, C. E.; Liu, H.-w. , Understanding and Exploiting Sugar Biosynthetic Enzymes and Natural Product Glycosyltransferases, Nature 446:1008-1016.|
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