Faculty

Michelle Lane

Lane, Michelle
Assistant Professor in Human Ecology, Division of Nutritional Sciences

E-mail

Website

Main Office: PAI 4.36C
Phone: 232-9410

Alternate Office: PAI 4.32
Phone: 471-4772

Mailing Address:
The University of Texas at Austin - Human Ecology
1 University Station A2700
GEA 117
Austin, TX 78712-1095
Research Lab Students:
  • Dillard, Alice
  • O'Reilley, Kally
  • Park, Eun Young
  • Wilder, Erik

    • Research Summary:

    Colorectal cancer is the third most common form of cancer and cause of death due to cancer in the United States. Currently, the five-year survival rate for colorectal cancer is only 62%, indicating an urgent need for more effective colon cancer chemotherapy. Retinoids are a family of chemicals containing vitamin A and its natural and synthetic derivatives. Retinoic acid is currently used as chemotherapy for leukemia and some forms of skin cancer. Unfortunately, chemotherapy with retinoic acid results in undesirable side effects and retinoic acid-resistant tumors are very common. Dr.Lane’s laboratory is investigating the ability of the dietary form of vitamin A, retinol, to inhibit the growth of retinoic acid resistant colon cancer cells. Dr. Lane and members of her laboratory have discovered that retinol inhibits colon cancer cell growth and metastasis. Retinol most likely inhibits these processes through a process involving Akt. Accutane is a oral retinoid used to treat severe acne. The link between clinical depression and Accutane is controversial due to numerous social and psychological factors that affect clinical depression frequency in adolescent humans. Recently, Dr. Lane's laboratory, in collaboration with Dr. Gonzalez-Lima in the Department of Psychology at UT-Austin and Dr. Sarah Bailey of the Department of Pharmacy and Pharmacology at Bath University, UK, showed that 13-cis-retinoic acid, the active ingredient in Accutane, induced depression-related behavior in adolescent mice. Members of Dr. Lane's laboratory are currently examining how 13-cis-retinoic acid changes gene expression and effects cell survival and metabolism resulting in this depressive behavior.
    Publications:
    2008M.A. Lane, J. Xu, E.W. Wilen, R. Sylvester, F. Derguini, L.J. Gudas, LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol, Mol Cell Endocrinol 280:63-74.
    2007E.-Y. Park, E. Wilder, and M.A. Lane, Retinol inhibits the migration and invasion of retinoic acid-resistant colon cancer cells in vitro and decreases matrix metalloproteinasem RNA, protein, and activity levels, Nutrition and Cancer 57:66-77.
    2006K. C. O'Reilly, J. Shumake, F. Gonzalez-Lima, M. A. Lane*, S. J. Bailey* (*the authors contributed equally to this work and share last author credit), Chronic Administration of 13-Cis-Retinoic Acid Induces Depression-Related Behavior in Mice, Neuropsychopharmacology 31:1919-1927.
    2005E.-Y. Park, A. Dillard, E. Williams, E. Wilder, M. R. Pepper, and M. A. Lane, Retinol Inhibits the Growth of Retinoic Acid-Resistant and Sensitive Colon Cancer Cells Through a Retinoic Acid Receptor-Independent Mechanism, Cancer Research 65:9923-9933.
    2005M.A. Lane and S.J. Bailey, Role of retinoid signaling in the adult nervous system, Progress in Neurobiology 75:275-293.

     
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