Associate Professor in Molecular Cell & Developmental Biology
Main Office: BIO 21B
Alternate Office: BIO 21/22
The University of Texas at Austin - ICMB
1 University Station A6700
205 W. 24th St.
Austin, TX 78712-1095
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Research Lab Students:
- Mulekar, Jidnyasa - Graduate Student
- Sharma, Nidhi - Graduate Student
- Zhu, Ling - Graduate Student
- bu, Qingyun - Post Doctoral
- Chen, Fulu - Post Doctoral
Our research is aimed at understanding light signal transduction, specifically those pathways mediated by the phytochrome (phy) family of sensory photoreceptors that absorb light in the red and far-red region of the spectrum. The phy system, consisting of five members in Arabidopsis (phyA-phyE), controls almost every aspect of the plant life cycle including seed germination, de-etiolation and flowering time. To understand early phy signaling events, phy interacting factors, such as PIF1, have been isolated and characterized. PIF1 is a basic helix-loop-helix (bHLH) transcription factor that interacts strongly with the biologically active form of phyA and phyB. PIF1 overexpression and pif1 mutants showed defective seedling de-etiolation including, aberrant hypocotyl elongation and developmentally regulated loss of greening, suggesting that PIF1 is a key regulator of the phy-mediated control of seedling de-etiolation process. Future projects include investigating the molecular function of PIF1, identifying and functionally characterizing PIF1 interacting proteins and PIF1 target genes using biochemical, genetic and functional genomic approaches.
|2011||Bu, Q., Zhu, L., Dennis, M., Yu, L., Lu, S.X., Person, M.D., Tobin, E.M., Browning, K. and Huq, E., Phosphorylation by CK2 enhances the rapid light-induced degradation of PHYTOCHROME INTERACTING FACTOR 1 in Arabidopsis, J. Biol. Chem. 286:12066-12074..|
|2010||Toledo-Ortíz, G., Huq, E. and Rodríguez-Concepción, M., Direct regulation of phytoene synthase gene expression and carotenoid biosynthesis by Phytochrome-Interacting Factors., Proc. Natl. Acad. Sci. USA 107:11626-11631.|
|2008||Shen, H., Ling, Z., Castillon, A., Majee, M., Downie, B. and Huq, E. , Light-induced phosphorylation and degradation of the negative regulator PIF1 depends upon its direct physical interactions with photoactivated phytochromes, Plant Cell 20:1586-1602.|
|2008||Moon, J., Zhu, L., Shen, H. and Huq, E., PIF1 directly and indirectly regulates chlorophyll biosynthesis to optimize the greening process in Arabidopsis, Proc. Natl. Acad. Sci. USA 105:9433-9438.|
|2004||Huq, E., Al-Sady, B., Hudson, M.E., Kim, C., Apel, K. and Quail, P.H. , PHYTOCHROME-INTERACTING FACTOR 1 is a critical bHLH regulator of chlorophyll biosynthesis. , Science 305:1937-1941..|
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