Faculty
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Ellington, Andy
Professor in Chemistry & Biochemistry
Wilson M. and Kathryn Fraser Research Professor In Biochemistry
E-mail Website Main Office: MBB 3.448B
Phone: 232-3424 Alternate Office: MBB 3.424
Phone: 471-6445 Mailing Address:
The University of Texas at Austin - ICMB
2500 Speedway
MBB 3.448BA
Austin, TX 78712-1095
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Research Lab Students:Caton, SarahChen, XiCho, Eun JeongDavidson, EricGates-Shannon, PhillipHall, BradleyHughes, RandyHwang, TonyLi, NaLu, Wei-ChengPai, SupriyaPodgornoff, DorothySingh, AmritaStovall, GwenSyrett, AngelWittig, MichaelYan, Amos
Research Summary:
The Ellington lab is primarily interesting in the evolutionary engineering of molecules, pathways, and organisms, and the application of these efforts to real world problems. In particular, we evolve functional RNA molecules that can function as diagnostic and therapeutic reagents, including RNA molecules that inhibit the replication of HIV-1 and tumor cells. We combine functional RNAs and other components into synthetic genetic circuits that can be used to control gene expression during gene therapy. We are also involved in the development of novel chimeras between biology and chemistry, including minimal replicators that can evolve outside of cells, light-dependent signal transduction pathways, and organisms that utilize unnatural amino acids in their proteomes.
Research Images:
Dr. Ellington's light induced Bacterial Photograph - Based on research published in Nature (Bacterial Photography: Engineering E. coli to see light; 438(7067):441-2) from Anselm Levskaya, Aaron A. Chevalier, Jeffrey J. Tabor, Zachary Booth Simpson, Laura A. Lavery, Matthew Levy, Eric A. Davidson, Alexander Scouras, Andrew D. Ellington, Edward M. Marcotte and Christopher A. Voigt. |
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Publications:| 2009 | Tabor, J.J., Salis, H.M., Simpson, Z.B., Chevalier, A.A., Levskaya, A., Marcotte, E.M., Voigt, C.A. and A.D. Ellington , A synthetic genetic edge detection program, Cell 137:1272-81. | | 2008 | Levy, M. and A.D. Ellington, Directed Evolution of Streptavidin Variants Using IVC, Chem Biol 15:979-989. | | 2006 | Chu, T.C., Twu, K.Y., Ellington, A.D., and M. Levy , Aptamer mediated siRNA delivery, Nucleic Acids Res 34:e73. | | 2006 | Chen, X., Denison, L., Levy, M. and A.D. Ellington, Direct Selection for ribozymen cleavage activity in cells, RNA. |
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